It seems that the majority of blogs all follow a standard layout: a long list of posts on the left and a sidebar on the right containing such things as recent comments, popular posts, etc. For this reason, when designing a blog, it is so important to do something innovative with the layout to help it stand out from the crowd.
Here are are 10 well designed blogs that all possess smart and innovative layouts. These should help inspire you to be different.
Here's some other articles that you will definitely find useful.